What Is Pyridine-4-boronic Acid CAS 1692-15-5? Identity, Applications, and Procurement Considerations
Pyridine-4-boronic acid, also called 4-pyridylboronic acid, is a heteroaryl boronic acid used as a building block in organic synthesis. Its CAS number is 1692-15-5, and its molecular formula is C5H6BNO2, with a molar mass of approximately 122.92 g/mol. The boronic acid group is attached at the 4-position of the pyridine ring, making the compound useful for forming carbon–carbon bonds in Suzuki–Miyaura cross-coupling reactions. For procurement, buyers should confirm the exact product form, assay basis, documentation, packaging, and delivery requirements rather than relying on the name and CAS number alone.
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Key Takeaways
- Pyridine-4-boronic acid is a nitrogen-containing aromatic boronic acid identified by CAS 1692-15-5.
- Its principal synthetic role is as a pyridyl coupling partner for preparing substituted pyridines and related compounds.
- Reaction performance depends on the coupling partner, catalyst, solvent, base, and conditions; the compound does not guarantee a particular yield.
- Before ordering, confirm whether the offered material is the anhydrous acid or another form, and agree on the required specification and documentation.
Identity and Chemical Structure
What the name describes
The molecule contains a six-membered aromatic pyridine ring, in which one ring position is occupied by nitrogen. At the ring’s 4-position, a carbon–boron bond connects the pyridyl group to a boronic acid moiety, commonly represented as B(OH)2. This combination gives the molecule both a heteroaromatic component and a functional group that can participate in selected bond-forming reactions.
The formula C5H6BNO2 and molar mass of approximately 122.92 g/mol describe the anhydrous acid. As a practical calculation, 1.00 mmol of the anhydrous compound corresponds to approximately 122.92 mg. If a supplier offers a hydrate, salt, solution, or other form, the mass calculation and specification should be checked against that form’s stated composition.
Identity checks for purchasing
CAS 1692-15-5 is a useful identifier, but it should be considered alongside the chemical name, formula, and product form. Product listings can use closely related naming conventions, and a hydrate or salt is not automatically interchangeable with the anhydrous acid on a mass-for-mass basis. We recommend asking suppliers to state the form supplied and the basis used for any assay or purity result.
Core Function in Organic Synthesis
The most recognized role of pyridine-4-boronic acid is as a nucleophilic coupling partner in Suzuki–Miyaura cross-coupling. In a typical reaction design, the pyridyl group is joined to an organic fragment bearing a suitable leaving group, often an aryl or heteroaryl halide. The exact outcome depends on the substrate pair and reaction system, including the catalyst, base, solvent, temperature, and other experimental variables.
For chemists, the practical value is the ability to introduce a pyridine ring into a larger molecular structure. Pyridine-containing fragments are found in many areas of synthetic research, but the presence of this building block alone does not establish a compound’s biological activity, commercial use, or suitability for a specific product. Those properties must be evaluated for the final molecule and its intended application.
Applications and Use Scenarios
Preparation of substituted pyridines
Researchers may use pyridine-4-boronic acid to prepare 4-substituted pyridine derivatives by coupling it with an appropriate reaction partner. This can support the synthesis of intermediates, reference compounds, and compound libraries in medicinal chemistry and other research programs. Whether the compound is suitable for a particular route should be confirmed through reaction-specific literature review or laboratory evaluation.
Heteroaromatic building-block work
The molecule can be considered when a synthesis calls for a pyridine ring connected to another aromatic or carbon-based fragment. Its position-specific functionality helps define where the new bond may be formed, while the pyridine nitrogen remains part of the resulting structure. Buyers working on multi-step routes should also consider compatibility with later steps, because reaction conditions that work for one coupling may not suit the full sequence.
Route development and screening
During process or route development, chemists may compare this reagent with alternative pyridyl donors or a route that installs the pyridine by a different transformation. Relevant evaluation points include conversion, selectivity, impurity profile, ease of work-up, and reproducibility at the intended scale. These are experimental questions, not properties that can be inferred solely from a supplier’s product description.
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Product Forms and Specification Considerations
Purchasers should verify whether the quoted material is the anhydrous acid or another stated form, such as a hydrate or salt. Differences in form can affect the calculated active content, handling, and amount weighed into a reaction. Do not assume that products with similar names share the same composition or assay basis.
Specifications are supplier- and grade-dependent, so we do not assign a universal purity, water content, appearance, or shelf life to this compound. For a purchase, review the current product specification and certificate of analysis where available, and confirm that the test methods and acceptance criteria meet your internal requirements. If a particular impurity limit or analytical method is necessary, state it before requesting a quotation.
Buyer Selection Factors
Match the material to the intended process
Begin by defining the application and the quantity required for evaluation or production. A laboratory screening project may have different needs from a scale-up campaign, especially for documentation, packaging, and lot consistency. Communicate the intended grade, quantity, target delivery location, and any handling or regulatory requirements that apply to your organization.
Confirm quality and documentation
Ask for the product specification, available analytical documentation, and batch-specific information relevant to your quality system. Clarify how assay is reported, whether the result is corrected for water or other components, and what analytical methods are used. If your process requires additional testing, such as a defined impurity profile, agree on feasibility and acceptance criteria before placing an order.
Assess packaging, lead time, and commercial terms
Request confirmation of pack size, packaging material, shipping conditions, minimum order quantity, and lead time for the requested quantity. Availability and delivery timing can vary with stock status, production planning, destination, and transport requirements, so obtain current confirmation rather than relying on general estimates. Compare quotations on the same basis, including product form, specification, quantity, documentation, and delivery terms.
Supplier Support from Maison Chemical
At Maison Chemical, we support B2B inquiries for Pyridine-4-boronic acid CAS 1692-15-5 by discussing the requested identity, specification, quantity, and destination. Buyers can share their target product form, quality requirements, packaging preference, and planned order volume so we can assess the request accurately. Product availability, lead time, and documentation should be confirmed for each inquiry.
For a technically specific request, include any required assay basis, impurity limits, analytical methods, or quality documents in your initial message. This helps us determine whether the requested specification can be matched and what information can be provided for the relevant batch. We do not treat a general product listing as a substitute for a project-specific specification review.
Conclusion and Next Steps
Pyridine-4-boronic acid CAS 1692-15-5 is a 4-pyridyl boronic acid building block, with a molar mass of approximately 122.92 g/mol, used primarily as a coupling partner in synthetic chemistry. Its usefulness depends on the target structure and the reaction conditions, while purchasing suitability depends on the exact form, specification, documentation, and supply terms. The CAS number identifies the requested substance, but buyers should still confirm the composition and assay basis before ordering.
To move forward, define the intended quantity and specification, identify any required documentation, and confirm the desired product form and delivery destination. Contact Maison Chemical with these details to request a quotation and verify current supply options for your project.