4-Trifluoromethoxyphenylboronic acid, also known as [4-(trifluoromethoxy)phenyl]boronic acid, is an aryl boronic acid used primarily as a building block in organic synthesis. Its CAS number is 139301-27-2, and its molecular formula is commonly reported as C7H6BF3O3, with a calculated molecular weight of approximately 205.93 g/mol. I recommend this material for research, medicinal chemistry, and process-development programs that require a para-trifluoromethoxy-substituted aryl group, subject to confirmation of the buyer’s reaction and specification requirements.
At Maison Chemical, I support B2B buyers with product identification, specification review, quotation preparation, packaging coordination, and export-oriented supply communication. Because physical properties and batch specifications can vary by manufacturing method and handling history, I advise customers to review the current certificate of analysis and safety documentation before placing a production order.
This guide is intended for procurement teams, research chemists, process-development groups, pharmaceutical and agrochemical manufacturers, and distributors sourcing 4-Trifluoromethoxyphenylboronic acid. It is also useful for buyers comparing suppliers for small development quantities or larger commercial sourcing programs. I focus on practical purchasing questions rather than treating the compound as a generic catalogue item.
The material may be relevant when a synthesis requires both an aryl boronic acid functionality and a trifluoromethoxy substituent. The boronic acid group provides a useful reaction handle, while the trifluoromethoxy group changes the electronic and lipophilic characteristics of the aromatic fragment. The final suitability must be confirmed through the buyer’s own reaction development, analytical, and safety procedures.
4-Trifluoromethoxyphenylboronic acid is an aromatic organoboron compound containing a phenyl ring substituted with a trifluoromethoxy group in the para position and a boronic acid group. The boronic acid functionality is the key synthetic feature because aryl boronic acids are commonly used in transition-metal-catalyzed carbon–carbon bond-forming chemistry, including Suzuki-type coupling reactions. The compound should not be confused with phenylboronic acid, trifluoromethoxybenzene, or other positional isomers.
| Parameter | Information |
|---|---|
| Product name | 4-Trifluoromethoxyphenylboronic acid |
| CAS number | 139301-27-2 |
| Molecular formula | C7H6BF3O3 |
| Approximate molecular weight | 205.93 g/mol |
| Compound class | Aryl boronic acid and organoboron building block |
I generally describe this product as a solid organic intermediate, but I do not treat appearance, melting behavior, assay, or water content as universal values without a batch-specific document. Buyers should request the current specification sheet and certificate of analysis for details such as appearance, identification, assay, moisture or loss on drying, residual solvents, and relevant impurity limits. A reported melting range, if required for release or incoming inspection, should also be confirmed against the exact supplied grade.
The boronic acid group can be sensitive to storage and handling conditions, and boronic acids may participate in equilibria or degradation pathways depending on moisture, temperature, concentration, and chemical environment. For that reason, I recommend keeping the product in its original, tightly closed packaging and following the supplier’s SDS and storage instructions. If a project has a long storage period or repeated container opening, the buyer should define an internal retest or requalification plan.
The most direct use is as a coupling partner in the preparation of biaryl or other aryl-substituted molecules. In a suitable Suzuki-type reaction, the aryl boronic acid can be combined with an appropriate aryl or heteroaryl halide under a validated catalytic and base system. Reaction performance depends on the substrate, catalyst, solvent, temperature, atmosphere, concentration, and work-up, so I do not recommend assuming that one published or internal condition will transfer without optimization.
Medicinal chemistry teams may select this building block when they want to introduce a para-trifluoromethoxyphenyl fragment into a lead series. The trifluoromethoxy substituent is chemically distinctive and can influence molecular properties, but its effect must be evaluated in the complete target molecule rather than inferred from the intermediate alone. The compound is therefore best treated as a defined synthetic input, not as a finished active ingredient.
Organoboron building blocks are also used in research programs for agrochemical, material, and specialty-intermediate synthesis. Whether this specific compound is appropriate depends on the desired molecular architecture and the downstream regulatory or technical requirements. I recommend that buyers provide the intended application category during quotation so that documentation, packaging, and supply planning can be aligned appropriately.
For most purchasing programs, the important distinction is not a broad “type” classification but the grade and documentation package supplied with the material. A research-grade quantity may be suitable for route scouting, while a process-development or manufacturing program may require tighter impurity control, defined packaging, repeat-batch consistency, and a documented change-control process. Buyers should specify whether they need a single development batch, repeat supply, or a qualified source.
I advise against selecting a supplier based only on a catalogue name and nominal purity. A useful specification must connect the analytical test to the buyer’s actual process risk, especially when the intermediate will be charged into a sensitive or multistep synthesis. If the buyer has a validated method, I can review the requested parameters before quotation.
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First, I recommend confirming the CAS number, para substitution pattern, molecular formula, and intended reaction role. Positional isomers can have different reactivity, analytical behavior, and commercial availability. The purchase order, product label, COA, and internal material master should use consistent identification information.
Next, define the minimum assay, impurity limits, water specification, packaging size, and retest expectations. If the material is for early-stage research, a practical specification may be sufficient; if it is for a regulated or scale-up process, the buyer may need more extensive analytical and change-control information. I can help separate essential release tests from optional characterization to avoid paying for documentation that does not reduce project risk.
Ask for a quotation that states pack size, available quantity, lead time, shipping terms, payment terms, and document availability. MOQ and lead time may depend on inventory, production scheduling, packaging configuration, and destination requirements, so I recommend requesting a project-specific quote rather than relying on a general web listing. For export orders, the buyer should also confirm whether special import, labeling, or transport documentation is required.
Before receiving the material, establish who will approve the SDS, how the container will be stored, and how unused material will be managed. Personnel should use the controls specified in the current SDS, including appropriate personal protective equipment and exposure prevention measures. I recommend that customers avoid transferring the material to unlabelled containers and document opening dates when stability is important.
One common mistake is comparing suppliers only by price per gram while ignoring assay basis, impurity limits, packaging, and freight. A lower unit price may not represent lower total cost if the material requires additional testing, repacking, or a longer lead time. Another mistake is requesting “high purity” without defining the analytical method or acceptance criteria.
Buyers should also avoid assuming that a compound listed as available is physically in stock in the requested quantity. I recommend confirming stock status, production timing, sample availability, and the validity period of the quotation before final approval. Finally, the buyer should check whether the intended application requires special documentation beyond a standard COA and SDS.
The cost of 4-Trifluoromethoxyphenylboronic acid can vary according to order quantity, purity target, packaging, analytical requirements, inventory position, and destination. MOQ is therefore best handled as a quotation variable rather than a fixed universal number. For an accurate offer, I ask buyers to provide the required quantity, target specification, delivery country, preferred packaging, and desired delivery window.
Small quantities may be suitable for route screening, while larger requirements may require production planning and a pre-shipment document review. If the project depends on repeat deliveries, I recommend discussing forecast quantities and acceptable batch-to-batch variation at the beginning. This approach helps reduce avoidable delays between laboratory validation and procurement release.
At Maison Chemical, I approach this product as a B2B sourcing requirement rather than a simple one-line catalogue transaction. I can assist with identity confirmation, specification alignment, quotation preparation, packaging discussion, and export documentation coordination for 4-Trifluoromethoxyphenylboronic acid CAS 139301-27-2. Where a customer has a specific quality or logistics requirement, I recommend reviewing it before order confirmation.
My supply process is designed to keep the buyer’s technical and commercial teams aligned. I can organize the relevant product documents, clarify what is confirmed versus quotation-dependent, and help identify the information needed for internal approval. Final acceptance should remain based on the agreed specification, current batch documentation, and the buyer’s own quality procedures.
4-Trifluoromethoxyphenylboronic acid CAS 139301-27-2 is a defined organoboron intermediate for projects requiring a para-trifluoromethoxy-substituted aryl building block. I recommend selecting it by verified identity, fit-for-purpose quality requirements, documented handling information, and dependable supply planning rather than by name or price alone. The next practical step is to send Maison Chemical your required quantity, purity target, packaging preference, destination, and delivery schedule.
I can then prepare a project-specific quotation and clarify the available documentation and supply conditions. Before release to production or research use, the buyer should review the supplied COA and SDS against internal acceptance criteria. This process provides a clearer basis for safe purchasing, technical evaluation, and future repeat supply.
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