I supply 4-(N-Boc-amino)phenylboronic acid, CAS 380430-49-9, as a specialty boronic acid intermediate for research, medicinal chemistry, and pharmaceutical development. This compound combines a protected aniline group with a phenylboronic acid functional group, making it useful for palladium-catalyzed Suzuki–Miyaura coupling and related synthetic routes. When evaluating this material, I recommend confirming identity, assay, water content, residual solvents, packaging, and batch documentation rather than selecting a supplier by price alone.
This guide explains how I would review the product specification, match it to a project, assess procurement factors, and evaluate a supplier such as Maison Chemical. Product availability, grade, minimum order quantity, lead time, and final release specifications should always be confirmed against the current batch documentation.
I prepared this guide for pharmaceutical and biotech research teams, medicinal chemistry groups, contract development and manufacturing organizations, chemical distributors, and procurement professionals sourcing 4-(N-Boc-amino)phenylboronic acid. It is also relevant to laboratories that need a protected aminophenyl building block for parallel synthesis or route-development work. The information is intended to support supplier discussions and specification review, not to replace project-specific analytical qualification.
4-(N-Boc-amino)phenylboronic acid is an aryl boronic acid containing a tert-butoxycarbonyl-protected amino group in the para position relative to the boronic acid functionality. The Boc group helps temporarily mask the aniline nitrogen during selected synthetic sequences, while the boronic acid can participate in carbon–carbon bond formation with suitable partners. The compound is commonly handled as a research or synthesis intermediate, so its suitability depends on the intended reaction and the buyer’s internal quality requirements.
| Item | Product information |
|---|---|
| Product name | 4-(N-Boc-amino)phenylboronic acid |
| CAS number | 380430-49-9 |
| Approximate molecular formula | C11H16BNO4 |
| Approximate molecular weight | 237.06 g/mol |
| Functional groups | Aryl boronic acid and Boc-protected aniline |
| Typical physical form | Solid; appearance and color should be confirmed by the batch specification |
The molecular formula and molecular weight shown above are useful for ordering and stoichiometric planning, but I recommend checking the supplier’s current technical data sheet before using them for regulated documentation. Boronic acids may show behavior influenced by hydration, handling, and storage conditions. For this reason, the actual certificate of analysis remains more important than a catalog description alone.
The principal application is as a building block in cross-coupling chemistry, especially when a protected para-amino aryl fragment is required. The boronic acid group can be paired with suitable aryl or heteroaryl halides under an appropriately developed Suzuki–Miyaura reaction system. After coupling, the Boc protecting group may be removed under acidic conditions when the free aniline is needed in a later step, subject to route compatibility.
I would not treat every batch as interchangeable for every application. A discovery-scale reaction may focus on identity and usable assay, while process development may require tighter controls for water, inorganic residues, palladium-related impurities, residual solvents, and lot-to-lot consistency. For advanced development, the buyer should define acceptance criteria before requesting a quotation.
A supplier specification for 4-(N-Boc-amino)phenylboronic acid should normally address identity, assay or purity, appearance, water content, residual solvents, and relevant impurities. Depending on the application, buyers may also request chromatographic data, proton and carbon NMR information, mass spectrometry, elemental analysis, or a method statement. I recommend distinguishing between routine release tests and optional tests that require separate agreement.
| Specification area | Why it matters to the buyer | What to request |
|---|---|---|
| Identity | Confirms that the material matches the ordered intermediate | CAS reference, NMR, MS, or another agreed identity test |
| Assay or purity | Supports reaction stoichiometry and impurity control | Analytical method, result, and reporting basis |
| Water content | May affect weighing, molar calculations, and moisture-sensitive chemistry | Karl Fischer result or agreed moisture specification |
| Residual solvents | Important for process chemistry and downstream control | Solvent profile and test method where required |
| Packaging and storage | Protects material quality during transport and warehouse handling | Container type, net weight, storage recommendation, and retest information |
I start by identifying the reaction stage, required batch size, and quality risk. For an early medicinal chemistry campaign, a small pack with standard analytical documentation may be appropriate. For route scouting or process work, I would request a representative sample first, compare the supplier’s analytical data with internal testing, and then discuss a larger lot.
With competitive price and timely delivery, Maison Chemical sincerely hope to be your supplier and partner.
A practical procurement target is to obtain at least one representative sample before committing to a large manufacturing quantity. I also recommend allowing a review period of approximately 3–5 business days for internal quality and technical assessment, although the actual time depends on the buyer’s procedures. If the material is intended for a regulated pathway, the quality agreement and documentation package should be discussed at the beginning rather than after the purchase order.
Pricing for this type of intermediate depends on pack size, purity target, manufacturing route, testing requirements, packaging, and whether the supplier is offering existing stock or a scheduled production batch. A low unit price may not represent the lowest total sourcing cost if it is paired with a large minimum order, limited documentation, or a long replenishment cycle. I suggest requesting separate quotations for sample, development, and bulk quantities.
Minimum order quantity should be matched to actual consumption and stability expectations. For a project with uncertain demand, staged purchasing can reduce inventory exposure, while a planned production campaign may justify a larger order if the supplier can provide consistent batch documentation. Lead time should be confirmed in writing because stock status and production scheduling can change.
At Maison Chemical, I approach this product as a sourcing and technical coordination requirement rather than a simple catalog transaction. I can discuss the intended application, required quantity, target specification, packaging, and documentation before preparing a quotation. Final availability, MOQ, lead time, and test items should be confirmed for each inquiry because they depend on the requested batch and service scope.
One common mistake is comparing suppliers solely by the advertised purity number without checking how that number is measured. Another is overlooking water content or residual solvent information when the material will enter a sensitive coupling or process-development route. Buyers should also avoid assuming that a product described as “Boc-amino phenylboronic acid” automatically has the same positional isomer, physical form, or analytical profile.
A second mistake is ordering a large quantity before confirming reaction performance. Boronic acid intermediates can require method-specific optimization, and a supplier’s standard specification cannot guarantee performance in every reaction system. I recommend evaluating a sample under the buyer’s actual conditions and documenting the acceptance decision before scale-up.
4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 is a useful protected aryl boronic acid intermediate for synthetic chemistry, particularly where a para-amino aryl fragment is needed after cross-coupling and later deprotection. The most important purchasing checks are correct identity, assay basis, water and residual solvent control, lot-specific documentation, packaging, and supply continuity. A supplier should be evaluated on technical transparency and service capability as well as price.
My recommended next step is to send Maison Chemical your target quantity, intended application, desired purity or internal specification, packaging preference, and documentation requirements. I can then help confirm the available grade, provide the relevant batch information, and prepare a quotation for sample, development, or larger-scale procurement. This approach gives your team a clearer basis for qualification and reduces avoidable sourcing risk.
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